NSP4 and ORF9b of SARS-CoV-2 Induce Pro-Inflammatory Mitochondrial DNA Release in Inner Membrane-Derived Vesicles
Circulating cell-free mitochondrial DNA (cf-mtDNA) has been Jiaogulan found in the plasma of severely ill COVID-19 patients and is now known as a strong predictor of mortality.However, the underlying mechanism of mtDNA release is unexplored.Here, we show a novel mechanism of SARS-CoV-2-mediated pro-inflammatory/pro-apoptotic mtDNA release and a rat