NSP4 AND ORF9B OF SARS-COV-2 INDUCE PRO-INFLAMMATORY MITOCHONDRIAL DNA RELEASE IN INNER MEMBRANE-DERIVED VESICLES

NSP4 and ORF9b of SARS-CoV-2 Induce Pro-Inflammatory Mitochondrial DNA Release in Inner Membrane-Derived Vesicles

Circulating cell-free mitochondrial DNA (cf-mtDNA) has been Jiaogulan found in the plasma of severely ill COVID-19 patients and is now known as a strong predictor of mortality.However, the underlying mechanism of mtDNA release is unexplored.Here, we show a novel mechanism of SARS-CoV-2-mediated pro-inflammatory/pro-apoptotic mtDNA release and a rat

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The Supercapsular Percutaneously Assisted Total Hip (SuperPATH) Approach Revisited: Technique Improvements after the Perioperative Experience of 344 Cases

The SuperPATH approach is a direct superior portal-assisted approach for total hip arthroplasty (THA) that utilizes the interval between the gluteus minimus and the piriformis to access the hip capsule.Patients and Methods: SuperPATH arthroplasty was performed by a single surgeon between December of 2016 and December of 2021 in 344 cases.The techni

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